About Thalassemia

Signs & Symptoms of Beta Thalassemia Intermedia or Major

Children with beta thalassemia intermedia or major may not show any symptoms at birth, but usually develop anaemia in the first 2 years of life. Signs of anaemia in beta thalassemia intermedia or major may include:

Extreme tiredness

Pale skin

Shortness of breath

Fast heartbeat

Irritability

Slow or delayed growth

Change in the shape of bones in the face and head

People with beta thalassemia intermedia or major also build-up extra iron in the body, either from the disease itself or from frequent blood transfusions. Extra iron can get deposited and damage the heart, liver, and endocrine system. To prevent that they need to take Regularly a special Medication called Iron Chelator.

People with beta thalassemia major may have other serious complications if not managed properly including:

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Bone deformities from changes in the bone marrow (where RBCs are made)
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An enlarged spleen and Liver. Doctors might need to remove the spleen if it gets too big or causes pain
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Gallstones. Doctors might need to remove the gallbladder if the stones cause pain or infection
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Infections, especially if doctors removed the spleen (the spleen helps fight some infections)
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Diabetes from damage to the pancreas and endocrine system